Conventional doses of venlafaxine have been shown capable of suppressing heart rate variability to a greater extent than other antidepressants, although the mechanisms are uncertain. A key limitation is that this research is observational, including collection and analysis of uncontrolled data. Venlafaxine is an SNRI, and increased concentrations of noradrenaline may be the underlying mechanism for the worsened heart failure. The authors recommended that SNRIs be avoided or used with caution and regular monitoring in patients with heart failure. Can Venlafaxine cause Heart Disease? Heart Disease is a known side effect of Venlafaxine. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Heart Disease is a known side effect of Venlafaxine. 1 The spectrum of acute heart failure after venlafaxine overdose M. BATISTA 1 DUGERNIER T . 2 M. SIMON 3 HA V . UFROID 4 A. , CAPRON 4 S. FONSECA 5 BONBLED. Objective. Large overdoses of venlafaxine may induce acute heart failure with severe left ventricular dysfunction. We describe two fatal cases of venlafaxine poisoning documented by post-mortem myocardial ultrastructural examination and by the determination of venlafaxine (VEN) and O-desmethylvenlafaxine (ODV) concentrations in cardiac tissue. We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services. In December 2004 the UK Medicines and Healthcare products Regulatory Agency (MHRA) restricted prescription of venlafaxine to specialists and contraindicated its use in patients with heart disease, electrolyte imbalance, or in patients who are hypertensive.15 16 After further review, in May 2006 the MHRA revised its regulatory position. 1. Ann Pharmacother. 2008 Jun;42(6):882-7. doi: 10.1345/aph.1L031. Epub 2008 Apr 29. Heart failure worsening and exacerbation after venlafaxine and duloxetine therapy. Two cases of interstitial pneumonia with cardiac failure developing in patients treated with the new antidepressant venlafaxine are presented. Introduction La venlafaxine et le propranolol ont été isolément incriminés dans de rares observations de pneumopathies médicamenteuses. Nous rapportons un cas de pneumopathie diffuse imputée à l’association des 2 molécules et discutons leur possible interaction.